Small integral membrane protein 10-like protein 1 (SMIM10L1)

Small integral membrane protein 10-like protein 1 (SMIM10L1) is a predicted membrane-associated protein with an α-helical structure that plays a role in regulating adipogenesis. Its downregulation promotes differentiation of adipose progenitor cells and is associated with increased PI3K/AKT/mTOR signaling and upregulation of the adipogenic transcription factor SREBP1. This suggests a possible role in adipose tissue biology and a potential contribution to lipoma formation, particularly in the context of PTEN Hamartoma Tumor Syndrome (PHTS). The gene is protein-coding, and while its full range of biological and disease associations remains incompletely understood, current evidence supports a function in adipose cell biology rather than direct action as a classical therapeutic target such as a receptor, enzyme, transporter, or ion channel[1][3][6].

Other names

SMIM10L1Small integral membrane protein 10 like 1Small integral membrane protein 10-like protein 1Chromosome X open reading frame 69-like