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Small integral membrane protein 11 (SMIM11)
- Target
- SMIM11
- Molecular classification
- Other (integral membrane protein; not classified as receptor, enzyme, transporter, ion channel, or transcription factor)
01
Overview
Small integral membrane protein 11 (SMIM11) is a protein of 58 amino acids with a predicted molecular weight of 6 kDa, encoded by the SMIM11 gene located on chromosome 21 in humans[1][5][10]. It is predicted and experimentally localized to membranes, including the cytoplasm, mitochondria, and focal adhesions, and contains a single transmembrane domain[1]. SMIM11 is expressed in multiple tissues, with highest mRNA levels observed in the brain, thyroid, and stomach, and detectable in heart, spleen, liver, muscle, lung, testis, skin, blood, and bone marrow[1][6][12]. The exact physiological role and protein partners of SMIM11 remain unknown, with no paralogs, no confirmed interacting proteins, and no direct link established to therapeutic targeting or disease mechanisms[1][3][4][8]. SMIM11 thus represents a small, conserved, uncharacterized integral membrane protein that is not currently considered a therapeutic target.
- Other names
- C21orf51FAM165BSMIM11ASMIM11Bsmall integral membrane protein 11Afamily with sequence similarity 165 member Bprotein FAM165B
02
Biological functions
Other (specific function not experimentally established; predicted as a membrane protein with protein binding function)
03
Disease associations
Other (no direct disease association; some databases note weak associations to rare metabolic or muscular dystrophy conditions, but no evidence of direct functional/disease role)
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