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Small integral membrane protein 22 (SMIM22)
- Target
- SMIM22
- Molecular classification
- Other (small integral membrane protein; not categorized as receptor, enzyme, transporter, ion channel, or transcription factor)
01
Overview
Small integral membrane protein 22 (SMIM22), also known as CASIMO1 (Cancer-associated small integral membrane open reading frame 1), is a protein-coding gene product found in humans. It is involved in the regulation of lipid droplet formation, cell migration, and actin cytoskeleton organization, likely through interaction with squalene epoxidase (SQLE). SMIM22 is predicted to be located in the late endosome and membrane and is expressed in multiple tissues. Its activity has been linked to cellular processes relevant to cancer, including cell proliferation and migration, but it is not formally recognized as a therapeutic target class such as a receptor, enzyme, or transporter[1][2][7][8].
- Other names
- CASIMO1Cancer-associated small integral membrane open reading frame 1cancer associated small integral membrane open reading frame 1
02
Biological functions
Lipid droplet formationRegulation of actin cytoskeleton organizationPositive regulation of cell migration
03
Disease associations
Cancer (notably described as cancer-associated; may participate in tumor cell proliferation and migration)
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