Small integral membrane protein 40 (SMIM40)

Small integral membrane protein 40 (SMIM40) is a predicted protein encoded by the human SMIM40 gene. It is annotated as a protein-coding gene and is thought to localize to cellular membranes, with possible additional localization in the nucleus[1][2]. There is no direct biochemical, physiological, or pharmacological characterization available, and no assigned functional roles, disease associations, or interacting compounds. It is not currently considered a drug target, and remains a poorly characterized or uncharacterized protein in major databases as of early 2025[1][2]. Essential Context & Supporting Details: - Protein size: SMIM40 comprises 79 amino acids[2]. - Gene locus: Human chromosome 6 (Ensembl ENSG00000286920)[1]. - Prediction: Annotations predict membrane localization due to sequence features, but experimental validation is lacking. It may have nuclear activity as well[1]. - Database status: UniProtKB entry Q5STR5 (reviewed, but marked as “function unknown”); GeneCards provides only basic genetic and predicted localization data, with no functional summary[1][2]. No evidence supports SMIM40 as a receptor, enzyme, transporter, transcription factor, or other well-classified target type. No molecular interactions or disease mechanisms have been published. No clinical, biological, or druggability relevance is established for this molecule, and no existing literature provides mechanistic insights beyond gene and predicted protein sequence annotation[1][2].

Other names

SMIM40Small integral membrane protein 40SIM40HGNC:54073NCBI Gene:113523636Ensembl ENSG00000286920UniProtKB Q5STR5