Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Small nuclear ribonucleoprotein-associated protein B (SNRPB)
- Target
- SNRPB
- Molecular classification
- snRNP core protein, RNA-binding protein, Spliceosomal component
01
Overview
Small nuclear ribonucleoprotein-associated protein B (SNRPB) is a highly conserved nuclear protein and a core component of spliceosomal small nuclear ribonucleoproteins (snRNPs), including U1, U2, U4/U6, and U5 particles essential for pre-mRNA splicing in eukaryotic cells[1][2]. It is also involved in the U7 snRNP complex for histone pre-mRNA 3'-end processing and is known to be a common autoantigen in systemic lupus erythematosus. Mutations are implicated in several congenital syndromes[1][2].
- Other names
- Small nuclear ribonucleoprotein-associated protein B'snRNP-BSm protein B/B'Sm-B/B'SmB/B'CODSNRPB1SmB/SmB'
02
Biological functions
Pre-mRNA splicingsnRNP structure assemblyHistone pre-mRNA 3′-end processing
03
Disease associations
Cancer (hepatocellular carcinoma, cervical cancer)Developmental disorders (cerebrocostomandibular syndrome, Pierre Robin syndrome)Autoimmunity (systemic lupus erythematosus autoantigen)
04
Safety considerations
Autoimmunity risk (as an autoantigen in SLE)non-druggable spliceosomal componentglobal inhibition risks severe cellular dysfunction
05
Biomarkers
Autoantibody target in systemic lupus erythematosus
Beyond the preview
Go deeper on Small nuclear ribonucleoprotein-associated protein B (SNRPB).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Small nuclear ribonucleoprotein-associated protein B (SNRPB).