Small nuclear ribonucleoprotein-associated protein N (SNRPN)

Small nuclear ribonucleoprotein-associated protein N (SNRPN) is a human protein encoded by the SNRPN gene and forms part of the small nuclear ribonucleoprotein (snRNP) complexes, specifically the Sm-class of snRNPs[1][5]. These complexes play a critical role in nuclear RNA processing, including pre-mRNA splicing and potentially tissue-specific alternative splicing events, acting within the spliceosome to remove introns from precursor mRNA[1][2][6]. SNRPN is involved in imprinting and gene regulation, particularly within the Prader-Willi syndrome critical region on chromosome 15; defects in this gene, such as abnormal imprinting, are linked to Prader-Willi syndrome[1][5]. SNRPN is not a conventional receptor, enzyme, or drug target, and there are no known drugs that directly interact with it or target it for therapeutic intervention. SNRPN methylation status is used clinically as a biomarker for diagnosing uniparental disomy in chromosome 15-related disorders[1].

Other names

Small nuclear ribonucleoprotein polypeptide NSNRPNSmN protein