Small nuclear ribonucleoprotein polypeptide F pseudogene 1 (SNRPFP1)

Small nuclear ribonucleoprotein polypeptide F pseudogene 1 (SNRPFP1) is a pseudogene-derived long non-coding RNA that is normally barely transcribed in healthy liver tissue but becomes anomalously activated and highly expressed in hepatocellular carcinoma (HCC)[1]. The transcript shows strong correlation with poor clinical outcomes in HCC patients, including larger tumor size, elevated serum alpha-fetoprotein levels, advanced TNM stages, tumor microsatellite formation, venous invasion, and liver cirrhosis[1]. SNRPFP1 functions as an oncogenic promoter by acting as a molecular sponge for the tumor-suppressive microRNA miR-126-5p, effectively sequestering this miRNA and preventing it from inhibiting cancer cell growth[1][2]. Experimental depletion of SNRPFP1 in HCC cell lines significantly suppresses cell proliferation, enhances apoptosis, impairs cell motility, and arrests the cell cycle at the G0/G1 phase[1]. The pseudogene demonstrates co-expression patterns with its parental gene SNRPF, which encodes a core component of spliceosomal small nuclear ribonucleoproteins involved in alternative splicing processes[1]. SNRPFP1 represents part of the molecular complexity driving tumor genesis, progression, and potential drug resistance in liver cancer, making it a promising target for HCC therapeutic strategies[2].

Other names

dJ1041C10.2SNRPF pseudogene 1

Competing endogenous RNA mechanism, microRNA sponging