Small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40)

Small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40; also known as WD repeat-containing protein 57 or WDR57) is a protein component of the U5 small nuclear ribonucleoprotein (snRNP) particle, which itself is a critical part of the spliceosome complex responsible for catalyzing intron removal from pre-messenger RNAs in eukaryotic cells. SNRNP40 contains WD repeat motifs that mediate protein–protein interactions, facilitating its role in the assembly and function of the U5 snRNP and, by extension, the spliceosome. While SNRNP40 is essential for proper splicing and RNA processing, it is not currently considered a direct therapeutic target, nor are there any approved drugs targeting this protein. However, components of the U5 snRNP complex (including proteins of similar or larger molecular weight) can be recognized by autoantibodies in autoimmune diseases such as systemic lupus erythematosus, highlighting its structural distinction and immunological relevance within the spliceosomal machinery.

Other names

SNRNP40WDR5740KHPRP8BPPRP8BPPRPF8BPSPF38small nuclear ribonucleoprotein U5 subunit 40small nuclear ribonucleoprotein U5 40 kDa subunitU5 small nuclear ribonucleoprotein 40 kDa proteinWD repeat-containing protein 57U5 snRNP 40 kDa proteinU5-40K