Small nucleolar RNA host gene 1 (SNHG1)

Small nucleolar RNA host gene 1 (SNHG1) is a long non-coding RNA (lncRNA) encoded by the SNHG1 gene in humans. It does not code for protein but regulates gene expression through multiple mechanisms, including acting as a molecular sponge for microRNAs, modulating DNA methylation, regulating transcription factors, and interacting with key tumor suppressor and oncogenic pathways. SNHG1 is frequently overexpressed in numerous cancers and is associated with promoting cell proliferation, invasion, and metastasis; it negatively regulates tumor suppressor genes such as p53 and contributes to poor prognosis when highly expressed. Alternative splicing of SNHG1 generates several small nucleolar RNAs. Although it is considered an emerging therapeutic target in cancer biology, there are currently no approved drugs specifically targeting SNHG1, and its main relevance is as an oncogenic driver and potential biomarker in solid tumors[1][2][3][4][7].

Other names

UHGNCRNA00057LINC00057lncRNA16U22 snoRNA host genenon-protein coding RNA 57long intergenic non-protein coding RNA 57U22HGU22 snoRNA host

No approved drugs, but experimental knockdown of SNHG1 (using siRNA or antisense oligonucleotides) inhibits cancer cell proliferation, invasion, and migration primarily via the modulation of specific miRNAs and gene pathways (e.g., as a competing endogenous RNA for miR-195, miR-326, miR-145; regulation of p53, Wnt/β-catenin pathway, Notch pathway)