Small nucleolar RNA host gene 10 (SNHG10)

Small nucleolar RNA host gene 10 (SNHG10) is a long non-coding RNA (lncRNA) that regulates gene expression through several molecular mechanisms including acting as a competing endogenous RNA (ceRNA); it is generally not translated into protein. SNHG10 is overexpressed in multiple human cancers such as colorectal cancer, prostate cancer, triple-negative breast cancer, and osteosarcoma, where it promotes tumor progression by enhancing cancer cell proliferation, migration, and invasion, often via sponging specific microRNAs (e.g., miR-3690). Elevated SNHG10 levels are associated with worse prognosis in some cancers. Preclinical studies show that SNHG10 knockdown suppresses tumor cell growth and migration, suggesting a therapeutic potential for RNA-based targeting approaches. SNHG10 is also under investigation as a diagnostic and prognostic biomarker due to its upregulation in tumor tissues. There are currently no approved drugs targeting SNHG10, and safety concerns (e.g., off-target effects, effective delivery) remain key challenges for translation to the clinic.

Other names

lncRNA SNHG10Small nucleolar RNA host gene 10SNHG10

Gene suppression via siRNA or antisense oligonucleotides (downregulation decreases proliferation, migration, invasion of cancer cells); Targeting lncRNA/miRNA interaction (e.g., modulating SNHG10/miR-3690 axis)