Small nucleolar RNA host gene 15 (SNHG15)

Small nucleolar RNA host gene 15 (SNHG15) is a long noncoding RNA located at chromosome 7p13, characterized by its short half-life and major cytoplasmic localization, indicating a role in post-transcriptional regulation[3][4]. Upregulated in numerous cancers, SNHG15 modulates cell proliferation, migration, invasion, apoptosis, and cell cycle through multiple mechanisms, including sponging specific miRNAs (e.g., miR-200a-3p, miR-451, miR-345-5p) and interacting with proteins to affect transcription and epigenetic states (e.g., recruitment of EZH2 to promote histone methylation and silencing tumor suppressors)[1][4][5]. SNHG15 also participates in chemoresistance (notably to gefitinib and 5-FU) and tumor progression, and its abnormal expression correlates with clinical features such as tumor stage and metastasis. Due to these roles, SNHG15 has emerged as a biomarker for cancer outcomes and represents a potential target for future RNA-based therapies[2][3][4].

Other names

FLJ38860MYO1GUTLinc-Myo1gMYO1G upstream transcriptC7orf40small nucleolar RNA host gene 15 (non-protein coding)SNHG15

Indirect modulation by influencing resistance via post-transcriptional gene regulation and interaction with miRNAs and signaling pathways (NOTCH-1, EGFR, YAP1/Hippo)