Small nucleolar RNA host gene 19 (SNHG19)

**Small nucleolar RNA host gene 19 (SNHG19)** is a long non-coding RNA (lncRNA) gene that acts as a host for the small nucleolar RNA SNORD60 and is located on chromosome 16p13.3[2][3]. As a lncRNA, SNHG19 does not code for a protein but is transcribed into a functional RNA molecule involved in regulating various cellular processes, notably in cancer biology[1][4][5]. SNHG19 is upregulated in several types of cancer tissues, including non-small cell lung cancer and breast cancer, where it promotes tumor progression by enhancing cell proliferation, migration, and invasion[1][4]. Mechanistically, SNHG19 acts mainly through a "competitive endogenous RNA" (ceRNA) pathway by sponging microRNAs such as miR-137, leading to the upregulation of oncogenes like E2F7, and thereby facilitating tumorigenesis[1][4]. Research suggests that SNHG19 may serve as a potential diagnostic and prognostic biomarker in cancers, especially lung and breast cancer, but no current data link it to any approved or experimental drugs, nor is it considered a direct therapeutic target, receptor, enzyme, or similar[2][3]. Unlike protein-coding targets, SNHG19 and other lncRNAs primarily exert their functions by regulating gene expression post-transcriptionally and epigenetically, and may play broader roles in tumorigenesis and potentially in immune regulation, as has been described for other SNHG family members[5]. There are no known interacting drugs or safety concerns specifically associated with targeting SNHG19, though targeting non-coding RNAs in general presents significant therapeutic challenges[5].

Other names

SNORD60 host geneSNORD60HGsmall nucleolar RNA host gene 19 (non-protein coding)SNHG19