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Target intelligence / Profile preview
Small nucleolar RNA host gene 29 (SNHG29)
- Target
- SNHG29
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
Small nucleolar RNA host gene 29 (SNHG29) is a long non-coding RNA primarily located in the nucleolus, predicted to be involved in RNA processing. It acts in cancer biology as a competing endogenous RNA (ceRNA), modulating gene expression by sponging tumor-suppressive microRNAs and impacting the p53/p21 pathway, DNA damage response, and therapeutic resistance (notably breast cancer chemoresistance). SNHG29 is associated with susceptibility to glioma, rheumatoid arthritis, and potentially other cancers, and is under investigation as a biomarker for tumor progression and malignancy stratification.
- Other names
- ACILMGC40157ATR and Chk1 interacting lncRNA (ACIL)C17orf45C17orf76-AS1FAM211A-AS1LRRC75A-AS1NCRNA00188TSAP19
02
Mechanism of action
ceRNA-mediated sequestration of miRNAs, modulation of p53/p21 signaling, interaction with ATR/Chk1 pathway, regulation of gene expression relevant to tumor progression and DNA damage response
03
Biological functions
Regulation of RNA processingmodulation of DNA damage responsecompeting endogenous RNA (ceRNA) activityregulation of cell senescence via p53/p21 signalingmodulation of gene expression via miRNA-mRNA axis
04
Disease associations
Cancer (including breast cancer chemoresistance)glioma susceptibilityrheumatoid arthritis
05
Safety considerations
Intrapopulation heterogeneity in expression and functionlimited understanding of off-target effects if therapeutically targeted
06
Biomarkers
Potential biomarker for cancerspecifically for breast cancer chemoresistance and as part of lncRNA signatures distinguishing disease states
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