Target intelligence / Profile preview

Small nucleolar RNA host gene 31 (SNHG31)

Target
SNHG31
Molecular classification
Long non-coding RNA (lncRNA), Non-protein-coding RNA, SNHG family
01

Overview

Small nucleolar RNA host gene 31 (SNHG31) is a member of the SNHG family, comprising long non-coding RNAs that typically serve as host transcripts for embedded small nucleolar RNAs (snoRNAs)[3][5]. Like other SNHGs, SNHG31 is not translated into protein but may regulate gene expression by acting as a scaffold for snoRNA processing, participating in epigenetic modification, influencing specific gene transcription by interacting with chromatin modifiers, and possibly acting as a competing endogenous RNA (ceRNA) to modulate microRNA activity[1][5]. Members of the SNHG family, including SNHG31, have been found upregulated in several types of cancer, where their expression often correlates with enhanced cell proliferation, decreased apoptosis, and poorer patient prognosis[1][5]. There are currently no approved drugs targeting SNHG31 directly, and its main importance lies in its regulatory role in gene expression and potential association with disease pathology, especially cancer[3][5].

Other names
SNHG31Small nucleolar RNA host gene 31
02

Mechanism of action

Not applicable, since there are no known interacting drugs specifically targeting SNHG31.

03

Biological functions

Regulation of gene expressionHost RNA scaffold for snoRNAsChromatin organization and epigenetic modificationCompeting endogenous RNA (ceRNA) function / miRNA spongingInfluence on ribosomal RNA modification and processing
04

Disease associations

Cancer
05

Biomarkers

Possibly cancer prognostic marker (as part of SNHG family)

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