Small nucleolar RNA SNORD22 (SNORD22)

Small nucleolar RNA SNORD22 (also known as snoRNA U22 or U22) is a non-coding RNA belonging to the box C/D class of snoRNAs, primarily functioning as a guide for site-specific 2′-O-methylation of nucleotides within ribosomal RNA and possibly small nuclear RNA[2][1][3]. It is typically located in the nucleolus, the main site of snRNA and rRNA maturation, and is encoded within the introns of the U22 host gene in mammals[2]. Like other C/D box snoRNAs, SNORD22 contains characteristic sequence motifs (C box and D box), associates with ribonucleoprotein complexes including fibrillarin and other core proteins, and plays a crucial role in ribosome biogenesis and potentially regulation of alternative splicing, but it is not considered a conventional therapeutic target such as a receptor, enzyme, or transporter[2][5][1][4].

Other names

snoRNA U22U22LOC124900306