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Small nucleolar RNA SNORD33 (SNORD33)
- Target
- SNORD33
- Molecular classification
- Non-coding RNA, Small nucleolar RNA (snoRNA), C/D box snoRNA family
01
Overview
Small nucleolar RNA SNORD33 is a non-coding RNA molecule of the box C/D class, characterized by conserved sequence motifs (C box and D box), and is typically found in the nucleolus of eukaryotic cells. It acts as a guide RNA, directing site-specific 2'-O-ribose methylation of substrate RNAs, most commonly ribosomal RNA, supporting proper ribosome function and biogenesis. SNORD33 is part of a multigene family, with related members including SNORD32 and SNORD34. It is not considered a classical therapeutic target but is important for basic cellular processes[2][3][4][5][6].
- Other names
- SNORD33snoRNA U33Small nucleolar RNA Z195C/D box snoRNAU33 snoRNA
02
Biological functions
2'-O-methylation of ribosomal RNAGuide RNA for site-specific RNA modificationRNA biogenesis within the nucleolus
03
Disease associations
SNORD33 dysregulation is being investigated in cancer and metabolic diseases, but its precise disease roles are still unclear; current evidence is indirect and largely from related snoRNAs in the family.
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