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Small nucleolar RNA SNORD42 (SNORD42)

Target: SNORD42
Molecular classification: Small nucleolar RNA (snoRNA), Non-coding RNA, C/D box snoRNA family, Guide RNA

Overview

Small nucleolar RNA SNORD42 (snoRNA U42, SNORD42A/B) is a short non-coding RNA found in the nucleolus of eukaryotic cells[2]. It belongs to the C/D box snoRNA family, characterized by conserved box C (UGAUGA) and box D (CUGA) motifs, and functions as a guide RNA directing site-specific 2'-O-methylation of ribosomal RNA, specifically the 18S rRNA[2][3][5]. SNORD42 is encoded within introns of the ribosomal protein L23a (RPL23a) gene in humans[2]. While not a classic therapeutic target, SNORD42 and related snoRNAs play vital roles in ribosome biogenesis and have been implicated as biomarkers and possible contributors to diseases such as cancer, where their differential expression might associate with prognosis or disease aggressiveness[1]. Regulatory strategies targeting snoRNAs (such as with antisense oligonucleotides) are under investigation for their therapeutic potential[1].

Other names: snoRNA U42SNORD42ASNORD42BMBII-287 (mouse ortholog)LOC124900890

Biological functions

Ribosomal RNA (rRNA) modification (specifically 2'-O-methylation)[2][3]Small nuclear RNA (snRNA) modification[2]RNA maturation and processing[2][4][5]Possibly involved in regulation of RNA biogenesis and processing[5]

Disease associations

Cancer (altered snoRNA expression, including SNORD42, is linked to cancer and may affect prognosis)[1]Biomarker for prognosis in colorectal cancer[1]

Safety considerations

Not applicable for direct drug targeting; however, general concerns for targeting snoRNAs include potential off-target effects and disruption of essential RNA modification processes[1][5]

Biomarkers

SNORD42 expression may serve as a predictive biomarker for prognosis in colorectal cancer patients[1]

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