Small nucleolar RNA SNORD81 (SNORD81)

Small nucleolar RNA SNORD81 is a member of the box C/D class of snoRNAs containing the conserved motifs C (UGAUGA) and D (CUGA). It functions as a guide RNA for 2′-O-methylation of other RNAs, most notably rRNA, by base pairing with its targets and recruiting the methyltransferase fibrillarin within the nucleolus. SNORD81 is generally encoded in intron 11 of the GAS5 gene in mammals and participates in the maturation and modification of ribosomal RNA, which is essential for accurate ribosome assembly and function. While aberrant expression or mutation of snoRNAs broadly can contribute to disease states, specific disease associations for SNORD81 have not been clearly established. It acts as part of small nucleolar ribonucleoprotein complexes (snoRNPs) and does not possess catalytic activity itself but directs enzymatic activity through its interactions with core proteins like fibrillarin, NOP56, NOP58, and SNU13.

Other names

U81Z23 snoRNALOC124900199

Not applicable (no drugs specifically target SNORD81; snoRNAs act as RNA guides rather than direct druggable entities)