Small nucleolar RNA U105C (RNU105C)

Small nucleolar RNA U105C is a non-coding RNA molecule of the box C/D class, found primarily in the nucleolus of eukaryotic cells. It forms part of small nucleolar ribonucleoprotein (snoRNP) complexes that direct the site-specific 2’-O-methylation of ribosomal RNA, an essential post-transcriptional modification required for correct ribosome biogenesis[3][5][1]. C/D box snoRNAs, including U105C, are characterized by conserved sequence motifs (boxes C and D) and interact with specific proteins such as fibrillarin to fulfill their function[1][3]. Dysregulation of snoRNAs in general has been associated with various diseases, especially cancer, although there is no direct evidence implicating U105C in specific disease mechanisms or as a drug or biomarker target at this time[5][4]. In summary, U105C is a small nucleolar RNA that participates in ribosomal RNA modification but is not a traditional therapeutic target or biomarker. While snoRNAs collectively have emerging roles in health and disease, information specific to U105C is limited.

Other names

E1-5E1-6U105CRNU105C

Not applicable — snoRNAs act as guides in ribonucleoprotein complexes to mediate site-directed 2'-O-methylation, not as typical drug targets.