Small organic guest molecules

Small organic guest molecules is a term derived from supramolecular chemistry, referring to chemical entities that are encapsulated or bound within the cavity of a larger host molecule through non-covalent interactions (Lehn, J. M., 1995, Supramolecular Chemistry). In a pharmacological context, these guest molecules are typically the drugs or active pharmaceutical ingredients (APIs) themselves, while the hosts, such as cyclodextrins or metal-organic frameworks, serve as delivery vehicles to enhance solubility or stability (Davis, M. E., & Brewster, M. E., 2004, Nature Reviews Drug Discovery). This term does not describe a biological macromolecule, such as a receptor, enzyme, or ion channel, that serves as a site of action for therapeutic intervention. Consequently, it is not classified as a therapeutic target in drug discovery or clinical medicine. Instead, it represents a structural role within a chemical complex or drug formulation system. Analysts should distinguish between the guest molecule, which is the therapeutic agent, and the biological target it is intended to modulate. Because it is a generic chemical classification rather than a specific biological entity, it is considered an incorrect entry for a therapeutic target database.

Other names

Guest moleculesOrganic guestsSmall molecule guests

Not applicable