Small proline-rich protein 2G (SPRR2G)

Small proline-rich protein 2G is a structural protein expressed in keratinocytes, where it contributes to the formation of the cornified envelope underlying the plasma membrane during terminal differentiation. It is cross-linked to membrane proteins by transglutaminase, supporting the physical barrier properties of the skin[1][2][5]. SPRR2G and other small proline-rich proteins play a role in epidermal homeostasis, keratinization, and response to external insults[4][6]. The SPRR gene family is upregulated in response to stress, inflammation, and skin pathology, and participates in keratinocyte differentiation. SPRR2G is regulated via upstream factors including estradiol and may interact with p73 and RBM38 regulatory loops, relevant to inflammation and tumor suppression in the context of related family members[3][6]. There is no evidence for direct modulation by therapeutic agents or validated clinical biomarker usage. SPRR2G is primarily a structural constituent of the epidermis, not a canonical pharmacologic target like a receptor or enzyme, but rather contributes to barrier formation and is implicated in skin differentiation and inflammatory responses[1][5][6].

Other names

Small proline rich protein 2GSPR-2GSPRR2GSPR2G

Not applicable; no known drugs target SPRR2G directly.