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Small ribosomal subunit protein uS10 (None)
- Target
- None
- Molecular classification
- Ribosomal Protein
01
Overview
Small ribosomal subunit protein uS10 (RPS20) is an essential component of the small (40S) ribosomal subunit, crucial for protein synthesis. It participates in ribosome assembly and mRNA decoding. uS10 plays a direct role in ribosome-associated quality control (RQC), where ubiquitination of lysine residues marks stalled ribosomes for degradation pathways. Disruptive mutations in RPS20 are associated with increased risk for hereditary colorectal carcinoma due to impaired quality control mechanisms.
- Other names
- RPS20Ribosomal protein S20uS10
02
Mechanism of action
Not applicable, as ribosomal proteins are typically not directly drugged
03
Biological functions
Ribosome AssemblyTranslationmRNA decodingRibosome-associated quality control (RQC)
04
Disease associations
Hereditary colorectal carcinomaDefects in pre-rRNA processing
05
Safety considerations
Mutations/deficiencies can lead to broad transcriptome/translatome changes
06
Biomarkers
RPS20 expression levels (potential biomarker for cancer risk)
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