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Small ribosomal subunit protein uS15 (RPS13)
- Target
- RPS13
- Molecular classification
- Other (Ribosomal protein, S15P family)
01
Overview
Small ribosomal subunit protein uS15 (RPS13) is a structural component of the 40S subunit of the eukaryotic ribosome, encoded by the RPS13 gene in humans. It is located in the cytoplasm and part of the S15P ribosomal protein family. RPS13 participates in ribosome assembly, binds rRNA, and is essential for protein translation. Mutations or disturbances in RPS13 have been linked to disorders such as Diamond-Blackfan anemia. As a ubiquitous and essential structural protein, it is not considered a classical therapeutic target but is fundamental to basic cellular biology[1][2][6][7].
- Other names
- 40S ribosomal protein S13ribosomal protein S13S13uS15
02
Biological functions
Protein synthesisrRNA bindingmRNA bindingribosome assemblystructural constituent of ribosome
03
Disease associations
Diamond-Blackfan anemiaChronic frontal sinusitisOther
04
Safety considerations
Essential for cell viability, broad inhibition would impair all protein synthesisnot a selective therapeutic target
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