Small ribosomal subunit protein uS5 (RPS2)

Small ribosomal subunit protein uS5 (RPS2) is a cytoplasmic protein that forms part of the 40S small subunit of the ribosome, an organelle responsible for catalyzing protein synthesis in eukaryotic cells[1][2][8]. RPS2 is involved in ribosome assembly, translation initiation, and RNA binding, and is crucial for accurate protein translation and cell viability[1][4][8]. It is a member of the S5P family of ribosomal proteins and plays critical roles in nucleolar processing of pre-18S ribosomal RNA and assembly of the functional ribosome[1][2]. Mutations in RPS2 have been linked to Diamond-Blackfan anemia[1]. Additionally, RPS2 can serve as a tumor antigen and may be suitable as a cancer biomarker or immunotherapeutic peptide but is not currently an established therapeutic target[3].

Other names

40S ribosomal protein S240S ribosomal protein S4Protein LLRep3LLREP3S2uS5RPS4OK/KNS-cl.6

Not applicable (no drugs currently target RPS2 directly for mechanism-of-action studies)