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Small ribosomal subunit protein uS8 (uS8)
- Target
- uS8
- Molecular classification
- Other (ribosomal protein), Ribosomal protein, Structural protein subunit
01
Overview
Small ribosomal subunit protein uS8 is a highly conserved structural component of the 40S subunit in eukaryotes (S15a in humans; RPS15A gene)[1][7]. It plays a crucial role in the assembly and stability of the small ribosomal subunit and binds directly to ribosomal RNA (16S rRNA in prokaryotes, or the analogous sequence in eukaryotes), helping coordinate the assembly of the ribosome platform essential for translation initiation[4][9]. While not a canonical drug target, its expression, function, and proper assembly are vital for cell growth and protein synthesis; defects or altered expression have been linked to impaired ribosome biogenesis and, in some contexts, cancer cell biology[6]. It is not targeted by approved drugs[9].
- Other names
- 40S ribosomal protein S15aRPS15A (in humans)Ribosomal protein S8
02
Mechanism of action
Not applicable for direct pharmacological targeting; antibiotics on bacterial ribosomes may inhibit the function of homologous proteins, but uS8 is not a common drug target in humans
03
Biological functions
Ribosome assemblyTranslation (protein synthesis)Ribosomal RNA binding
04
Disease associations
Cancer (not as a direct driver, but as a marker or functional player in ribosome biogenesis in cancer cells)Other (ribosomopathies, rare disorders of ribosome function; general roles in cell proliferation)
05
Safety considerations
General safety concerns are related to disruption of core ribosomal proteins, which is essential for cell viability. No specific therapeutic targeting, and loss of function is lethal for normal cells.
06
Interacting drugs
None known as direct, clinically used drugs target uS8 specifically. There are ribosome-targeting antibiotics that act on the small ribosomal subunit, but not on uS8 in humans
07
Biomarkers
RPS15A (the human gene encoding uS8) has been studied as a potential biomarker for cancer cell proliferation and for ribosome biogenesis status in some cancer lines
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