Target intelligence / Profile preview

Small ribosomal subunit protein uS9 (uS9)

Target: uS9
Molecular classification: Ribosomal protein, Structural constituent of the small ribosomal subunit[6][8], Other

Overview

Small ribosomal subunit protein uS9 is a highly conserved structural component of the 30S (small) subunit of prokaryotic and eukaryotic cytoplasmic ribosomes. It plays an essential role in stabilizing the structure of the small subunit and facilitating accurate mRNA decoding during translation by interacting with tRNAs at the P site. The C-terminal tail contributes to tRNA affinity at this site, influencing translational fidelity. While critical for cell viability due to its role in global protein synthesis, it is not considered a druggable therapeutic target nor associated with any selective pharmacological agents[1][5][7].

Other names: 30S ribosomal protein S9 (in bacteria)Ribosomal protein S9rpsI (gene name in Escherichia coli)[5]RPS9 (gene symbol in eukaryotes)

Mechanism of action

Not applicable; there are no drugs with mechanisms targeting this specific molecule.

Biological functions

Protein synthesis/translation[1][8]Structural stabilization of the small (30S) ribosomal subunit[1]Facilitates tRNA binding at the P site during translation elongation and initiation[5][7]

Disease associations

There are no direct disease roles established for this specific structural component. Mutations may affect general cellular viability due to impaired translation but are not directly linked to specific diseases.

Safety considerations

Not applicable as it is not targeted therapeutically. Inhibition or mutation would likely be cytotoxic due to disruption of essential cellular function.

Interacting drugs

No known drugs directly target small ribosomal subunit protein uS9 specifically. However, some antibiotics target bacterial small ribosomal subunits broadly but do not selectively bind to uS9.

Biomarkers

None known for patient selection or efficacy monitoring.

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