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Small subunit processome component 20 homolog (UTP20)
- Target
- UTP20
- Molecular classification
- Other (ribosome biogenesis factor; nucleolar protein)
01
Overview
Small subunit processome component 20 homolog (UTP20) is a highly conserved, nucleolar protein and integral part of the small subunit (SSU) processome, which is a large ribonucleoprotein complex crucial for the early steps of eukaryotic ribosome biogenesis[1][5]. UTP20 is required for processing and maturation of the 18S rRNA and the assembly of the small ribosomal subunit[1][3]. The SSU processome includes UTP20 among more than 70 proteins and U3 small nucleolar RNA, acting as an architectural and scaffolding factor[1]. In humans, reduced levels of UTP20 have been linked to cancer metastasis, where it has been referred to as "down-regulated in metastasis" protein[2]. UTP20 does not fall into classic target categories such as receptor, enzyme, transporter, or ion channel, and is not currently a recognized direct target for therapeutic drugs.
- Other names
- 1A6/DRIMDRIMNNP73down-regulated in metastasis proteinnovel nucleolar protein 73protein Key-1A6down regulated in metastasisUTP20 small subunit (SSU) processome componentUTP20, small subunit (SSU) processome component, homolog
02
Biological functions
Ribosome biogenesisPre-rRNA processingAssembly of the small ribosomal subunit
03
Disease associations
Cancer (notably down-regulated in metastasis)Other (potential, limited information)
04
Biomarkers
Down-regulated in metastasis (potential biomarker for cancer progression)
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