Target intelligence / Profile preview

Small Ubiquitin-Related Modifier Protein (SUMO)

Target: SUMO
Molecular classification: Ubiquitin-like modifier, Protein

Overview

Small ubiquitin-related modifier proteins (SUMOs) are a family of small proteins structurally similar to ubiquitin. They are covalently attached to lysine residues on target proteins in a process known as SUMOylation, which is a type of post-translational modification. SUMOylation regulates various cellular processes including nuclear-cytosolic transport, transcriptional regulation, DNA repair and replication, mitosis, apoptosis, and protein stability.

Other names: SUMO1SUMO2SUMO3

Mechanism of action

Selective degradation of SUMO1; Modulation of SUMOylation pathways

Biological functions

Nuclear-cytosolic transportTranscriptional regulationDNA replication and repairMitosisSignal transductionProtein stability

Disease associations

Developmental disorders (e.g., cleft lip/palate)Cardiac dysfunctionCancer

Interacting drugs

SUMO1 degraders

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