SMG1 pseudogene 3 (SMG1P3)

SMG1 pseudogene 3 (SMG1P3) is a processed pseudogene related to the SMG1 gene, which encodes a serine/threonine-protein kinase involved in nonsense-mediated mRNA decay (NMD)[3][7]. SMG1P3 itself is not transcribed into a functional protein product and thus is not considered functionally active in biological processes. It is sometimes referenced in genomic annotation due to sequence similarity to the functional SMG1 gene, but it does not play a role in therapeutic targeting, disease biology, or molecular function in cells[3][7][8]. SMG1P3 should not be confused with SMG1, which is a functional kinase involved in the NMD pathway and DNA damage response, and is investigated as a potential therapeutic target in some contexts. The designation "pseudogene" in SMG1P3 means it lacks protein-coding capacity and functional activity[7][3][8].

Other names

SMG1P3, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 3smg-1 homolog, phosphatidylinositol 3-kinase-related kinase pseudogeneSMG1P3

Not applicable; no mechanism due to pseudogene status