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Target intelligence / Profile preview
Smooth Muscle Cells (SMCs)
- Target
- SMCs
- Molecular classification
- Cell Type, Muscle Cell
01
Overview
Smooth muscle cells (SMCs) are specialized, spindle-shaped cells found in the walls of hollow organs, including blood vessels, intestines, bladder, and uterus. They are responsible for involuntary movements, such as peristalsis, and regulate vascular tone. SMC replacement aims to regenerate or replenish these cells in tissues where they have been lost or damaged due to disease. Pericytes serve as a primary source for regeneration, differentiating into new SMCs after injury. While promising for regenerative medicine, challenges remain regarding the specificity of targeting and ensuring proper functional integration within host tissues.
- Other names
- Vascular Smooth Muscle CellsVisceral Smooth Muscle CellsMyocytes (Smooth Muscle Type)
02
Mechanism of action
N/A - Cells, not a specific protein target
03
Biological functions
ContractionRegulation of vascular tonePeristalsisMaintenance of structural integrityVasoconstrictionVasodilation
04
Disease associations
AtherosclerosisRestenosisHypertensionArteriosclerosisAneurysmsGastrointestinal motility disordersBladder dysfunctionUterine dysfunction
05
Safety considerations
Non-specific targetingIncomplete integration into existing tissue architectureOff-target effects during cell replacement therapiesPotential for fibrosis or scar tissue formationRisk of tumorigenesis with stem cell-derived therapies
06
Biomarkers
Myh11TaglnActa2Platelet-derived growth factor receptor β
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