Target intelligence / Profile preview

Smoothened (SMO)

Target: SMO
Molecular classification: G protein-coupled receptor, Class Frizzled GPCR

Overview

Smoothened (SMO) is a transmembrane protein and a member of the Class Frizzled (Class F) G protein-coupled receptor (GPCR) family. It plays an essential role in the Hedgehog (Hh) signaling pathway, which is crucial for embryonic development, tissue patterning, and adult tissue homeostasis. Dysregulation of Hedgehog/SMO signaling can result in developmental disorders or contribute to oncogenesis, such as basal cell carcinoma and medulloblastoma.

Mechanism of action

SMO antagonists inhibit SMO, preventing activation of the Hedgehog pathway.

Biological functions

Signal transductionEmbryonic developmentTissue homeostasis

Disease associations

CancerDevelopmental disorders

Safety considerations

Resistance to SMO inhibitors due to secondary mutations

Interacting drugs

Cyclopamine

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