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Smoothened Frizzled Class G Protein-Coupled Receptor (SMO)
- Target
- SMO
- Molecular classification
- G protein-coupled receptor, Class Frizzled GPCRs
01
Overview
Smoothened (SMO) is a transmembrane protein belonging to the Class Frizzled family of G protein-coupled receptors (GPCRs). It plays a central role in the hedgehog signaling pathway, which is crucial for embryonic development and adult tissue homeostasis. SMO acts as a signal transducer regulated by Patched (PTCH). Upon activation, SMO initiates intracellular signaling events that regulate gene expression critical for developmental processes. Mutations or dysregulation of SMO are implicated in several diseases, notably cancer. Therapies like vismodegib target SMO to inhibit aberrant Hh signaling.
- Other names
- FZD11frizzled family member 11bnb
02
Mechanism of action
Inhibition of Smoothened signaling
03
Biological functions
Signal transductionCell differentiationCell proliferationTissue homeostasisRegulation of gene expression
04
Disease associations
Cancer
05
Safety considerations
Drug resistanceTeratogenicity (Cyclopamine)Potential for off-target effects
06
Interacting drugs
Vismodegib
1 more in the full profile.
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