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Target intelligence / Profile preview
Smoothened frizzled class receptor (SMO)
- Target
- SMO
- Molecular classification
- G protein-coupled receptor, Receptor, Class Frizzled GPCR
01
Overview
The Smoothened frizzled class receptor (SMO) is a seven-transmembrane G protein-coupled receptor (GPCR) and a key component of the Hedgehog (Hh) signaling pathway. It is indirectly regulated by the Patched (PTCH) protein. When Hh ligands are absent, PTCH inhibits SMO. Binding of Hh to PTCH relieves this inhibition, leading to SMO activation and downstream signaling. SMO plays a critical role in embryonic development and tissue homeostasis, and its dysregulation is implicated in various cancers. SMO is a drug target, with inhibitors like vismodegib used to treat advanced basal cell carcinoma. However, resistance can arise due to mutations in SMO.
- Other names
- FZD11frizzled family member 11
02
Mechanism of action
SMO inhibitors bind to the transmembrane domain of the receptor, blocking its activation and downstream signaling.
03
Biological functions
Signal transductionEmbryogenesisTissue patterningCell differentiationCell proliferationHedgehog signaling
04
Disease associations
CancerDevelopmental disordersTumorigenesis
05
Safety considerations
Drug resistance due to mutations in SMO
06
Interacting drugs
Vismodegib
1 more in the full profile.
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