SMT3 suppressor of mif two 3 homolog 1 pseudogene

SMT3 suppressor of mif two 3 homolog 1 pseudogene (ENSG00000213655) is a human pseudogene corresponding to the yeast *SMT3* gene, and is annotated as a nonfunctional copy of the gene encoding a small ubiquitin-like modifier (SUMO1). Pseudogenes do not produce functional proteins and are not therapeutic targets; confusion may arise due to the existence of active SUMO1, SUMO2, and SUMO3 genes, which play important roles in post-translational modification of proteins by sumoylation, impacting nuclear transport, DNA repair, mitosis, and more. This pseudogene is not implicated in disease, pharmacology, or as a biomarker. ENSG00000213655 is explicitly annotated as a pseudogene in all prominent genetic databases. The related functional gene is **SUMO1** (Small Ubiquitin-Like Modifier 1), which is involved in sumoylation of proteins in various cellular processes, but this record refers only to the pseudogene, which does not encode any functional protein product. There is potential for confusion because the nomenclature and homology relate to important protein modifiers (SUMO family), but this locus is not functionally active. There are no drugs, actionable mechanisms, or biomarker roles associated with this pseudogene, and it should not be considered a therapeutic or pharmacological target.

Other names

AC010493.1SUMO1 pseudogeneSUMO1P1