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SMT3 suppressor of mif two 3 homolog 2 pseudogene (ENSG00000243659) is a non-protein-coding pseudogene in the human genome[8][3][5]. It is homologous to the yeast SMT3 gene, which is the founding member of the SUMO (Small Ubiquitin-like Modifier) protein family. Functional SUMO proteins (such as SUMO2 and SUMO3) act as post-translational modifiers of other proteins, regulating processes such as nuclear transport, DNA repair, cell cycle progression, and transcriptional regulation. However, this specific pseudogene does not code for a functional protein and is not known to have a direct biological, disease, or therapeutic role in humans[8][3][5][6]. If you are interested in the functional versions, consider searching for SUMO2 or SUMO3 (e.g., "Small ubiquitin like modifier 2" or "Small ubiquitin like modifier 3"), which are active proteins with significant roles in cell biology[6]. The current query, however, points to a pseudogene and not a valid molecular target.
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