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Target intelligence / Profile preview
Snail family transcriptional repressor 3 (SNAI3)
- Target
- SNAI3
- Molecular classification
- Transcription factor, Zinc finger protein, C2H2-type zinc finger protein
01
Overview
Snail family transcriptional repressor 3 (SNAI3) is a zinc finger transcription factor and member of the Snail protein family, which includes SNAI1 and SNAI2. SNAI3 functions as a transcriptional repressor by binding to canonical E-box DNA sequences (CAGGTG and CACCTG), thereby inhibiting the transactivation of target genes, particularly those involved in muscle cell differentiation. Highest expression levels are observed in thymus and skeletal muscle. Unlike SNAI1 and SNAI2, which have well-defined roles in epithelial-mesenchymal transition and tumor progression, SNAI3's physiological role in mammals remains less well characterized, and knockout studies in mice indicate it is not essential for embryogenesis[1][3][4][5].
- Other names
- Zinc finger protein SNAI3ZNF293SMUCZfp293Protein snail homolog 3Snail homolog 3Snail family zinc finger 3
02
Biological functions
Transcriptional repressionInhibition of myoblast differentiationRegulation of gene expression during development
03
Disease associations
Other (no direct links to major human diseases, but related Snail family proteins are involved in cancer, EMT, and development)
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