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Target intelligence / Profile preview
SNAP25 antisense RNA 1 (SNAP25-AS1)
- Target
- SNAP25-AS1
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
SNAP25 antisense RNA 1 (SNAP25-AS1) is a human long non-coding RNA gene located antisense to the SNAP25 locus. It does not encode a protein. SNAP25-AS1 is predicted to be involved in processes such as SRP-dependent cotranslational protein targeting to the membrane and signal sequence recognition based on computational analyses. Recent studies suggest that SNAP25-AS1 plays a role in cancer biology, particularly in lung cancer, where it is included in lncRNA-based prognostic signatures and is implicated in hypoxia-associated gene regulatory networks. Its specific molecular function and precise biological roles remain under investigation, and it is not considered a conventional therapeutic target, nor are there drugs known to modulate it directly.
- Other names
- SNAP25-AS1SNAP25 antisense RNA 1 (non-protein coding)SNAP25 antisense RNA 1ENSG00000227906 (Ensembl)NCBI Gene: 100131208HGNC: 44312
02
Mechanism of action
Not applicable.
03
Biological functions
Speculated involvement in SRP-dependent cotranslational protein targeting to membraneSignal sequence recognition
04
Disease associations
Implicated in cancer biology, specifically as a component of prognostic lncRNA signatures in lung cancerInvolved in hypoxia-induced pathways in lung cancer and potentially other cancer-related gene regulatory networks
05
Biomarkers
SNAP25-AS1 is a prognostic biomarker candidate in lung cancer, as part of multi-lncRNA panels predictive for disease progression and patient outcomesMay be integrated in competitive endogenous RNA (ceRNA) networks affecting cancer phenotypes
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