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SNARE Complex (SNARE)
- Target
- SNARE
- Molecular classification
- Protein Complex, Membrane Fusion Protein
01
Overview
The SNARE complex is a multi-protein complex that mediates the fusion of synaptic vesicles with the presynaptic membrane, leading to neurotransmitter release. Key components include Syntaxin, SNAP25, VAMP/Synaptobrevin, Complexin, and Synaptotagmin. The complex is essential for calcium-triggered exocytosis and is a target for toxins like botulinum toxin.
- Other names
- Acetylcholine transporter protein complexSoluble NSF Attachment Protein Receptor ComplexSynaptic Vesicle Fusion Machinery
02
Mechanism of action
Inhibits neurotransmitter release by cleaving SNARE proteins
03
Biological functions
Neurotransmitter ReleaseVesicle TraffickingMembrane FusionExocytosis
04
Disease associations
Neurological DisordersNeurodegenerative DiseasesSynaptic DysfunctionMotor Neuron Diseases
05
Safety considerations
Botulinum toxin is highly toxic and can cause paralysisDysregulation of SNARE complex function can lead to various neurological disorders
06
Interacting drugs
Botulinum toxin
1 more in the full profile.
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