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SNCA messenger RNA (SNCA mRNA)
- Target
- SNCA mRNA
- Molecular classification
- RNA, mRNA
01
Overview
The SNCA messenger RNA (mRNA) is the transcript produced from the SNCA gene, which encodes the protein alpha-synuclein. This mRNA is crucial for the synthesis of alpha-synuclein, a neuronal protein highly abundant in the brain. Targeting SNCA mRNA is a therapeutic strategy aimed at reducing alpha-synuclein production in neurodegenerative diseases characterized by its toxic aggregation. Key regulatory elements like the iron-responsive element (IRE) in the 5' UTR and genetic regulatory elements (*cis*-acting sequences like Rep1) offer points for therapeutic intervention.
- Other names
- Alpha-synuclein mRNA
02
Mechanism of action
Inhibition of SNCA mRNA translation; reduction of SNCA mRNA abundance
03
Biological functions
Template for protein synthesisRegulation of alpha-synuclein expressionSynaptic vesicle trafficking regulation (indirect)Neurotransmitter release modulation (indirect)Possible influence on microtubule movement (indirect)Possible DNA repair (indirect)
04
Disease associations
Parkinson’s diseaseMultiple system atrophyNeurodegenerative disease
05
Safety considerations
Off-target effects of mRNA-targeting therapeuticsPotential for unintended consequences of altering alpha-synuclein expressionDelivery challenges for brain-penetrant mRNA-targeting drugs
06
Interacting drugs
Synucleozid
1 more in the full profile.
07
Biomarkers
SNCA mRNA levels in cerebrospinal fluidSNCA mRNA levels in bloodAlpha-synuclein protein levels
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