SNF2 family ATP-dependent chromatin remodeling ATPase (Snf2 ATPase)

SNF2 family ATP-dependent chromatin remodeling ATPases are enzymes that use the energy released from ATP hydrolysis to modify the structure of chromatin, thereby regulating access to DNA for processes such as transcription, replication, and repair. They are characterized by a conserved ATPase domain with DExD (DEAD) box helicase motifs, though they generally *do not* function as classic DNA helicases for strand separation, but rather translocate along DNA to disrupt or reposition nucleosomes[1][2][3]. The family includes numerous subfamilies and members within eukaryotes, each with additional regulatory domains; for example, the mammalian proteins SMARCA2, SMARCA4 (BRG1), CHD1, and INO80. Mutations or alterations in these proteins are implicated in development, cancer, and other diseases. This entry refers to a **family of proteins**, not a single canonical human gene or protein. For structured, programmatic use, you should select a specific family member for detailed mapping.

Other names

SWI/SNF ATPasechromatin remodeling ATPaseSMARCASNF2-like ATPaseDExD box ATPaseSWI2/SNF2 family protein

Drugs targeting members of this family typically aim at ATPase inhibition (blocking ATP hydrolysis), inhibition of chromatin remodeling activity, or modulation of protein-protein interactions within chromatin complexes.