SNRPN upstream reading frame pseudogene

The SNRPN upstream reading frame pseudogene (ENSG00000225046) is a nonfunctional genomic sequence that shares homology with the SNRPN upstream open reading frame (SNURF) gene, which encodes a nuclear protein in humans. Unlike protein-coding genes, pseudogenes do not produce functional proteins and generally lack regulatory or physiological roles, although transcripts from some pseudogenes may be processed into regulatory RNAs in rare cases[1][2][5][8]. This pseudogene has no recognized therapeutic relevance, disease association, or direct biological function, and is generally not of pharmacological or clinical interest[1][2][5].\n\nThe related functional gene is "SNRPN upstream open reading frame" or SNURF, which is implicated in imprinting disorders such as Prader-Willi and Angelman syndromes, but ENSG00000225046 as a pseudogene does not have the same clinical or biological significance[1][9].\nPseudogenes like ENSG00000225046 are commonly present throughout the genome and are nonfunctional by definition[2][5]. Only rarely do pseudogenes acquire secondary regulatory roles.\n\nFor structured information or pharmacological research, focus on the functional SNURF gene rather than its pseudogenes.

Other names

SNURF pseudogene