Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sodium–Glucose Cotransporter 2 (SGLT2)
- Target
- SGLT2
- Molecular classification
- Solute carrier family, Sodium-glucose cotransporters, Transporter
01
Overview
The sodium–glucose cotransporter 2 (SGLT2) is a membrane protein primarily responsible for the reabsorption of glucose from the glomerular filtrate in the kidneys. It is a therapeutic target for type 2 diabetes, chronic kidney disease, and heart failure. Inhibition of SGLT2 leads to increased urinary excretion of glucose and sodium, providing therapeutic benefits.
- Other names
- SLC5A2Solute carrier family 5 member 2
02
Mechanism of action
Inhibition of SGLT2 promotes urinary excretion of glucose and sodium, leading to reduced blood glucose levels, weight loss, and blood pressure reduction. May also have effects on adipose tissue lipolysis and gut microbiome composition.
03
Biological functions
Renal glucose reabsorptionSodium transportGlucose homeostasis
04
Disease associations
Type 2 diabetesChronic kidney diseaseHeart failureCardiovascular disease
05
Interacting drugs
Canagliflozin
2 more in the full profile.
Beyond the preview
Go deeper on Sodium–Glucose Cotransporter 2 (SGLT2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sodium–Glucose Cotransporter 2 (SGLT2).