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Target intelligence / Profile preview
Sodium/Hydrogen Exchanger 1 (NHE1)
- Target
- NHE1
- Molecular classification
- Transporter, Membrane protein
01
Overview
NHE1 is a ubiquitously expressed sodium/hydrogen antiporter that plays a critical role in regulating intracellular pH and cell volume. It catalyzes the electroneutral exchange of one intracellular proton (H+) for one extracellular sodium ion (Na+), contributing to cellular homeostasis, especially under conditions of acid load or cell shrinkage. Beyond its ion transport function, NHE1 acts as a scaffold for signaling complexes and interacts with cytoskeletal elements, influencing processes such as cell migration, survival, and response to mechanical stimuli. Dysregulation of NHE1 is implicated in various pathologies including cardiac hypertrophy/failure and cancer progression.
- Other names
- SLC9A1Sodium–hydrogen antiporter 1Na+/H+ exchanger isoform-1
02
Mechanism of action
Inhibition of Na+/H+ exchange
03
Biological functions
Ion exchangeRegulation of intracellular pHCell volume regulationCell adhesionCell migrationScaffoldingMechanotransductionCell survivalHypoxia adaptation
04
Disease associations
Cardiac hypertrophyHeart failureCancer progressionCancer metastasisDuchenne muscular dystrophyDisorders involving disrupted cellular pH or volume control
05
Safety considerations
Potential for off-target effects due to ubiquitous expressionElectrolyte imbalances
06
Interacting drugs
Amiloride
1 more in the full profile.
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