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Target intelligence / Profile preview
Sodium–Hydrogen Exchanger Type 1 (NHE-1)
- Target
- NHE-1
- Molecular classification
- Transporter, Ion exchanger
01
Overview
NHE-1 is a ubiquitously expressed plasma membrane protein that functions as an electroneutral antiporter, exchanging one intracellular proton (H⁺) for one extracellular sodium ion (Na⁺). This process is crucial for maintaining intracellular pH and cell volume homeostasis. It is involved in various physiological processes and implicated in several diseases, including cardiovascular diseases and cancer.
- Other names
- Sodium–hydrogen antiporter 1sodium/hydrogen exchanger 1
02
Mechanism of action
Inhibition of Na+/H+ exchange
03
Biological functions
Intracellular pH regulationCell volume homeostasisCell survivalActin cytoskeleton organization
04
Disease associations
HypertensionHeart diseaseIschemia-reperfusion injuryCancer progressionMetastasis
05
Safety considerations
Potential for off-target effects due to ubiquitous expressionDisturbance of pH balance
06
Interacting drugs
Amiloride
2 more in the full profile.
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