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Sodium- and chloride-dependent GABA transporter 1 (GAT1)
- Target
- GAT1
- Molecular classification
- Transporter, Solute Carrier Family 6 (SLC6)
01
Overview
Sodium- and chloride-dependent GABA transporter 1 (GAT1) is a membrane protein responsible for the reuptake of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. It mediates transport of GABA together with sodium (Na⁺) and chloride (Cl⁻) ions, removing GABA from the synaptic cleft by shuttling it into presynaptic neurons or astrocytes. This process is essential for terminating synaptic transmission and recycling neurotransmitter. Disruption or dysfunction in SLC6A1/GAT1 activity has been implicated in neurological disorders such as epilepsy.
- Other names
- GABA transporter 1SLC6A1
02
Mechanism of action
Inhibition of GABA reuptake
03
Biological functions
Neurotransmitter reuptakeTermination of synaptic transmissionRegulation of inhibitory neurotransmissionGABA recycling
04
Disease associations
EpilepsyNeurological disorders
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