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Alginate

Molecular classification
Other (natural polysaccharide, exopolysaccharide, carbohydrate)
01

Overview

Alginate is a linear copolymer composed of β-D-mannuronic acid and α-L-guluronic acid residues, found naturally in the cell walls of brown seaweed[2][3][5]. Alginate forms gels in the presence of divalent cations (e.g., Ca²⁺), and its chemical properties are determined by the ratio and sequence of M and G monomers. Commercially, alginate is widely used as a hydrogel, stabilizer, thickener, and wound dressing, and is an excipient in drug delivery systems due to its biocompatibility, biodegradability, and ability to form stable gels[1][2][4][6]. Alginate is not a classical therapeutic target, receptor, or enzyme, but is a biomaterial and formulation agent. Occasionally, it plays a biological role in bacterial biofilms, notably in the pathogenicity of Pseudomonas aeruginosa in cystic fibrosis[5].

Other names
Alginic acidsodium alginatecalcium alginatepotassium alginatealginAlloid Gpoly(mannuronic acid), sodium saltKaltostatbarium alginatecopper alginatesodium calcium alginateXantalginVocoloid
02

Biological functions

Structural component of brown algae cell wallsForms hydrogels and biofilmsUsed in biofabrication (implant scaffolds), wound healing, drug deliveryProvides viscosity and gelation to solutionsIn bacteria (e.g., Pseudomonas aeruginosa), promotes biofilm formation and antibiotic resistance
03

Disease associations

Other (used in wound healing, tissue engineering, not directly a disease target)Infection (as a biofilm matrix in Pseudomonas aeruginosa, implicated in cystic fibrosis lung infections)
04

Safety considerations

Allergic reactions (rare, related to seaweed or impurities)Biocompatibility (generally high, but purity and source may affect safety profile)Potential for microbial contamination in unrefined extracts

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