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Target intelligence / Profile preview
Sodium-and chloride-dependent gamma aminobutyric acid transporter 3 (None)
- Target
- None
- Molecular classification
- Transporter, Neurotransmitter:sodium symporter family (SLC6)
01
Overview
GAT3 is a high-affinity, sodium- and chloride-dependent plasma membrane transporter responsible for the uptake of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. It mediates GABA reuptake into glial cells, primarily astrocytes, playing a crucial role in terminating synaptic GABA action, regulating extracellular GABA levels, and modulating neuronal excitability.
- Other names
- Solute carrier family 6 member 11Gamma aminobutyric acid transporter type 3
02
Mechanism of action
Sodium/chloride-dependent symporter
03
Biological functions
Neurotransmitter reuptakeRegulation of extracellular GABA levelsModulation of neuronal excitability
04
Disease associations
EpilepsyAlcoholismNeuropsychiatric conditions
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