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Sodium Bile Acid Cotransporter (None)
- Target
- None
- Molecular classification
- Transporter, Solute Carrier, SLC10 family
01
Overview
The sodium bile acid cotransporters, including NTCP (SLC10A1) and ASBT (SLC10A2), are membrane transport proteins mediating sodium-dependent uptake of bile acids. NTCP, primarily in hepatocytes, facilitates hepatic uptake of bile acids from portal blood. ASBT, in ileal enterocytes, is responsible for reabsorption of intestinal bile acids, contributing to enterohepatic circulation and bile acid homeostasis. They are therapeutic targets for conditions like liver disease, irritable bowel syndrome and NASH. NTCP is the receptor for HBV entry into cells.
- Other names
- NTCPSLC10A1LBATFHCA2ASBTIBATISBTNTCP2SLC10A2Na+-taurocholate cotransporting polypeptideIleal sodium/bile acid cotransporter
02
Mechanism of action
Inhibition of intestinal bile acid reuptake.
03
Biological functions
Bile acid transportEnterohepatic circulationSodium-dependent transport
04
Disease associations
CholestasisLiver diseaseIrritable Bowel SyndromeNon-alcoholic steatohepatitisLipid metabolism disordersHepatitis B Virus infection
05
Safety considerations
Potential for drug-drug interactions affecting bile acid metabolismImpact on lipid absorptionSide effects related to altered bowel function
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