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Target intelligence / Profile preview
Sodium-calcium exchanger 1 (NCX1)
- Target
- NCX1
- Molecular classification
- Transporter, Ion exchanger
01
Overview
NCX1 is a ubiquitously expressed membrane protein that plays a critical role in cellular calcium homeostasis. It mediates the electrogenic exchange of one Ca(2+) ion for three to four Na+ ions across the plasma membrane, typically exporting Ca(2+) from the cytoplasm in exchange for Na+. This process is essential for cardiac muscle relaxation, control of neurosecretion, activity of photoreceptor cells, and maintenance of low cytoplasmic Ca(2+) concentration in various cell types. Dysregulation or abnormal activation can contribute to pathologies such as delayed afterdepolarization leading to arrhythmias in heart tissue due to aberrant depolarizing currents when excess intracellular calcium activates NCX-mediated sodium influx.
- Other names
- SLC8A1
02
Mechanism of action
Inhibition of Na+/Ca2+ exchange
03
Biological functions
Calcium homeostasisCardiac muscle relaxationNeurosecretion controlPhototransductionIon transport
04
Disease associations
ArrhythmiasIschemia/reperfusion injuryNeurodegenerative diseases
05
Safety considerations
Potential for pro-arrhythmic effectsOff-target effects of non-selective inhibitors
06
Interacting drugs
KB-R7943 mesylate
5 more in the full profile.
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