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Target intelligence / Profile preview
Sodium channel modifier 1 (SCNM1)
- Target
- SCNM1
- Molecular classification
- RNA splicing factor, Zinc finger protein, RNA-binding protein
01
Overview
Sodium channel modifier 1 (SCNM1) is a zinc finger protein acting as an RNA splicing factor and component of the minor spliceosome, particularly involved in the splicing of U12-type introns in pre-mRNAs[6][2][3]. It directly participates in the splicing process by interacting with spliceosome proteins (U1-70K, Smith (Sm) proteins) and can modify the phenotypic expression of mutations in the sodium channel gene Scn8a, especially in mouse[1][2]. SCNM1 may also regulate primary cilia length and Hedgehog signaling[6]. This gene is recognized as a *modifier* of the effects of sodium channel gene mutations and is not an ion channel or receptor itself, nor is it a direct pharmacological target[2][6].\nNo known drugs, biomarkers, or direct therapeutic roles for SCNM1 in humans are described.
- Other names
- MGC3180OFD19TNFAIP8L2-SCNM1sodium channel modifier 1SCNM1TNFAIP8L2-SCNM1 protein
02
Biological functions
RNA splicingModifier of splicing for sodium channel gene (Scn8a)Regulation of primary cilia lengthHedgehog signaling
03
Disease associations
Modifier gene for phenotypes associated with sodium channel mutationsOrofaciodigital syndrome (OMIM: 608095)potentially influences disease severity indirectly
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